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high resolution spatial rna seq platform  (Complete Genomics Inc)


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    Complete Genomics Inc high resolution spatial rna seq platform
    High Resolution Spatial Rna Seq Platform, supplied by Complete Genomics Inc, used in various techniques. Bioz Stars score: 99/100, based on 472 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/stereo+seq+spatial+transcriptomics+platform/Stereo-seq+Transcriptomics+Set+for+FFPE/pm41792309-65-15-20
    Average 99 stars, based on 472 article reviews
    high resolution spatial rna seq platform - by Bioz Stars, 2026-10
    99/100 stars

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    Spatial Transcriptomics:

    Article Title: Somatic structural variants drive upper tract urothelial carcinoma muscle invasiveness via activation of TPX2 transcription.
    Article Snippet: .. 6 www.thelancet.com Vol 125 ▪, 2026 Spatial transcriptomics data generation and analysis Formalin-fixed paraffin-embedded (FFPE) urothelial carcinoma tissue sections were profiled using the Stereo-seq spatial transcriptomics platform (MGI, China) according to the manufacturer’s protocols. ..

    Article Title: Somatic structural variants drive upper tract urothelial carcinoma muscle invasiveness via activation of TPX2 transcription
    Article Snippet: .. Formalin-fixed paraffin-embedded (FFPE) urothelial carcinoma tissue sections were profiled using the Stereo-seq spatial transcriptomics platform (MGI, China) according to the manufacturer's protocols. ..

    Formalin-fixed Paraffin-Embedded:

    Article Title: Somatic structural variants drive upper tract urothelial carcinoma muscle invasiveness via activation of TPX2 transcription.
    Article Snippet: .. 6 www.thelancet.com Vol 125 ▪, 2026 Spatial transcriptomics data generation and analysis Formalin-fixed paraffin-embedded (FFPE) urothelial carcinoma tissue sections were profiled using the Stereo-seq spatial transcriptomics platform (MGI, China) according to the manufacturer’s protocols. ..

    Article Title: Somatic structural variants drive upper tract urothelial carcinoma muscle invasiveness via activation of TPX2 transcription
    Article Snippet: .. Formalin-fixed paraffin-embedded (FFPE) urothelial carcinoma tissue sections were profiled using the Stereo-seq spatial transcriptomics platform (MGI, China) according to the manufacturer's protocols. ..



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    Spatial transcriptomic delineation of TPX2 positive epithelial cells and their tumour microenvironmental interactions in UTUC. A. Representative haematoxylin and eosin (H&E)-stained sections (left) and corresponding spatial transcriptomic cell-type annotations (right) from MI (upper) and NMI (lower)-UTUC biopsy, scale bar = 1 mm. Spatial spots were annotated by integrating spatial <t>transcriptomics</t> with single-cell reference datasets, revealing the spatial organisation of epithelial tumour populations and diverse TME components. B. Box plots showing TPX2 expression levels across major spatially defined cell types in MI-UTUC biopsy. TPX2 expression was significantly enriched in basal epithelial tumour cells and specific urothelial tumour subpopulations compared with immune and stromal compartments (∗∗∗∗, P < 0.0001; Wilcoxon rank-sum test). C. Bar plot comparing the proportion of TPX2 positive spots across spatial cell types between MI- and NMI-UTUC samples. TPX2 positive epithelial tumour populations were markedly enriched in MI-UTUC relative to NMI-UTUC. D. Box plots showing average epithelial mesenchymal transition (EMT) signature scores in spatial neighbours of TPX2 positive versus TPX2 negative epithelial tumour cells. Neighbourhoods surrounding TPX2 positive cells exhibited significantly higher EMT associated transcriptional activity (P = 3.33 × 10 −3 ; Wilcoxon rank-sum test), indicating localisation of TPX2 positive tumour cells within invasion-promoting microenvironments. E. Bar plot showing log2 fold changes of EGFR- and EPHA2-associated ligand expression in spatial neighbours of TPX2 positive compared with TPX2 negative epithelial tumour cells.
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    Spatial transcriptomic delineation of TPX2 positive epithelial cells and their tumour microenvironmental interactions in UTUC. A. Representative haematoxylin and eosin (H&E)-stained sections (left) and corresponding spatial transcriptomic cell-type annotations (right) from MI (upper) and NMI (lower)-UTUC biopsy, scale bar = 1 mm. Spatial spots were annotated by integrating spatial <t>transcriptomics</t> with single-cell reference datasets, revealing the spatial organisation of epithelial tumour populations and diverse TME components. B. Box plots showing TPX2 expression levels across major spatially defined cell types in MI-UTUC biopsy. TPX2 expression was significantly enriched in basal epithelial tumour cells and specific urothelial tumour subpopulations compared with immune and stromal compartments (∗∗∗∗, P < 0.0001; Wilcoxon rank-sum test). C. Bar plot comparing the proportion of TPX2 positive spots across spatial cell types between MI- and NMI-UTUC samples. TPX2 positive epithelial tumour populations were markedly enriched in MI-UTUC relative to NMI-UTUC. D. Box plots showing average epithelial mesenchymal transition (EMT) signature scores in spatial neighbours of TPX2 positive versus TPX2 negative epithelial tumour cells. Neighbourhoods surrounding TPX2 positive cells exhibited significantly higher EMT associated transcriptional activity (P = 3.33 × 10 −3 ; Wilcoxon rank-sum test), indicating localisation of TPX2 positive tumour cells within invasion-promoting microenvironments. E. Bar plot showing log2 fold changes of EGFR- and EPHA2-associated ligand expression in spatial neighbours of TPX2 positive compared with TPX2 negative epithelial tumour cells.
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    Image Search Results


    Spatial transcriptomic delineation of TPX2 positive epithelial cells and their tumour microenvironmental interactions in UTUC. A. Representative haematoxylin and eosin (H&E)-stained sections (left) and corresponding spatial transcriptomic cell-type annotations (right) from MI (upper) and NMI (lower)-UTUC biopsy, scale bar = 1 mm. Spatial spots were annotated by integrating spatial transcriptomics with single-cell reference datasets, revealing the spatial organisation of epithelial tumour populations and diverse TME components. B. Box plots showing TPX2 expression levels across major spatially defined cell types in MI-UTUC biopsy. TPX2 expression was significantly enriched in basal epithelial tumour cells and specific urothelial tumour subpopulations compared with immune and stromal compartments (∗∗∗∗, P < 0.0001; Wilcoxon rank-sum test). C. Bar plot comparing the proportion of TPX2 positive spots across spatial cell types between MI- and NMI-UTUC samples. TPX2 positive epithelial tumour populations were markedly enriched in MI-UTUC relative to NMI-UTUC. D. Box plots showing average epithelial mesenchymal transition (EMT) signature scores in spatial neighbours of TPX2 positive versus TPX2 negative epithelial tumour cells. Neighbourhoods surrounding TPX2 positive cells exhibited significantly higher EMT associated transcriptional activity (P = 3.33 × 10 −3 ; Wilcoxon rank-sum test), indicating localisation of TPX2 positive tumour cells within invasion-promoting microenvironments. E. Bar plot showing log2 fold changes of EGFR- and EPHA2-associated ligand expression in spatial neighbours of TPX2 positive compared with TPX2 negative epithelial tumour cells.

    Journal: eBioMedicine

    Article Title: Somatic structural variants drive upper tract urothelial carcinoma muscle invasiveness via activation of TPX2 transcription

    doi: 10.1016/j.ebiom.2026.106182

    Figure Lengend Snippet: Spatial transcriptomic delineation of TPX2 positive epithelial cells and their tumour microenvironmental interactions in UTUC. A. Representative haematoxylin and eosin (H&E)-stained sections (left) and corresponding spatial transcriptomic cell-type annotations (right) from MI (upper) and NMI (lower)-UTUC biopsy, scale bar = 1 mm. Spatial spots were annotated by integrating spatial transcriptomics with single-cell reference datasets, revealing the spatial organisation of epithelial tumour populations and diverse TME components. B. Box plots showing TPX2 expression levels across major spatially defined cell types in MI-UTUC biopsy. TPX2 expression was significantly enriched in basal epithelial tumour cells and specific urothelial tumour subpopulations compared with immune and stromal compartments (∗∗∗∗, P < 0.0001; Wilcoxon rank-sum test). C. Bar plot comparing the proportion of TPX2 positive spots across spatial cell types between MI- and NMI-UTUC samples. TPX2 positive epithelial tumour populations were markedly enriched in MI-UTUC relative to NMI-UTUC. D. Box plots showing average epithelial mesenchymal transition (EMT) signature scores in spatial neighbours of TPX2 positive versus TPX2 negative epithelial tumour cells. Neighbourhoods surrounding TPX2 positive cells exhibited significantly higher EMT associated transcriptional activity (P = 3.33 × 10 −3 ; Wilcoxon rank-sum test), indicating localisation of TPX2 positive tumour cells within invasion-promoting microenvironments. E. Bar plot showing log2 fold changes of EGFR- and EPHA2-associated ligand expression in spatial neighbours of TPX2 positive compared with TPX2 negative epithelial tumour cells.

    Article Snippet: Formalin-fixed paraffin-embedded (FFPE) urothelial carcinoma tissue sections were profiled using the Stereo-seq spatial transcriptomics platform (MGI, China) according to the manufacturer's protocols.

    Techniques: Staining, Spatial Transcriptomics, Single Cell, Expressing, Activity Assay